伦理高清百度影音伦理高清百度影音
Ming Yi Ph.D.
Principal Investigator
Laboratory for Cognitive Neuroscience
Neuroscience Research Institute
Peking University
38 Xueyuan Road
Beijing 100083， China
Tel: + 86(0)10 8280 5083
Email: mingyi@hsc.pku.edu.cn
Academic experience
Dr. Yi received his medical degree in Peking University Health Science Center， and Ph.D. training in John O’Keefe (2014 Nobel laureate) group in the Department of Anatomy and Developmental Biology of University College London (UCL). Dr. Yi is currently a principal investigator and leads the Laboratory for Cognitive Neuroscience in Neuroscience Research Institute of Peking University.
Research: Decoding， manipulating and reconstructing memory
Learning and memory are crucial cognitive functions for daily life， whereas pathological memories underlie a variety of neuropsychiatric diseases such as post-traumatic stress disorder and chronic pain. Yi lab， with combinative application of in vivo and in vitro electrophysiology， two-photon calcium imaging， opto- and chemo-genetics and molecular biology， focuses on decoding， manipulating and reconstructing memory and other brain functions， and aims to develop novel assessment and intervention tools for various neuropsychiatric disorders.
(1) Neuronal basis and functional reconstruction of the memory system
Memory traces are encoded and stored by subpopulations of interconnected engram cells widely distributed in the brain. Yi lab combined neuronal labeling with gene editing techniques， and erased specific fear memories in rats by gene editing in circuit- and function-specific neuronal subpopulations (Sci Adv. 2020). Yi lab further demonstrated that abnormal activity patterns of fear engram cells constituted core neuronal basis of cognitive and affective changes in neuropsychiatric disorders characterized by generalized fear (PLoS Biol. 2024). Yi lab is currently developing novel medicinal and neuromodulatory techniques to reconstruct memory functions in patients of post-traumatic stress disorder and perioperative neurocognitive disorder.
(2) Neuronal and circuitry basis of pain memory
Pain is a complex symptom involving perceptual， affective， cognitive and social dimensions. Chronic pain has been described as pathological memories for nociception and suffering. Decoding pain signals is a challenging task， since no brain regions specifically encode pain. Yi lab reported prefrontal neuronal subpopulations and circuits that encode evoked pain (Cell Rep. 2022)， spontaneous pain (Cell Rep. 2019) and comorbid anxiety (Autophagy. 2024) in rodent models of chronic pain， and revealed how the limbic system participated in pain encoding and modulation (J Neurosci. 2017; Pain. 2018; Cell Rep. 2023).
(3) Assessment and rehabilitation of brain functions in infants
Accurate assessment of brain injury， development and function in infants directly affects diagnosis， intervention and prognosis of various brain disorders such as cerebral palsy， growth retardation and autism. Yi lab developed a video tracking- and AI-based system for automatic assessment of general movements in infants (Med Image Anal. 2024; Displays. 2024). Currently， Yi lab works on a series of novel clinical tools for assessment and rehabilitation of brain functions in infants.
Representative publications
Cui K， Qi X， Liu L， Jiao P， Tong J， Sun X， Sun H， Fu S， Wang J， Zheng Y， Liu T， Cui S， Liu F， Zheng J， Wan Y， Yi M. Dominant activities of fear engram cells in the dorsal dentate gyrus underlies fear generalization. PLoS Biol. 2024. In press
Yin W， Chen L， Huang X， Huang C， Wang Z， Bian Y， Wan Y， Zhou Y， Hang T， Yi M. A self-supervised spatio-temporal attention network for video-based 3D infant pose estimation. Med Image Anal. 2024. 96:103208
Huang X， Huang C， Yin W， Huang H， Xie Z， Huang Y， Chen M， Fan X， Shang X， Peng Z， Wan Y， Han T， Yi M. Automatic quantitative intelligent assessment of neonatal general movements with video tracking. Displays. 2024. 82:102658
Fu S， Sun H， Wang J， Gao S， Zhu L， Cui K， Liu S， Qi X， Guan R， Fan X， Liu Q， Chen W， Su L， Cui S， Liao F， Liu F， Wong CL， Yi M， Wan Y. Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain. Autophagy. 2024. Mar 24:1-18
Shao S， Zheng Y， Fu Z， Wang J， Zhang Y， Wang C， Qi X， Gong T， Ma L， Lin X， Yu H， Wan Y， Zhang H， Yi M. Ventral hippocampal CA1 modulates pain behaviors in mice with peripheral inflammation. Cell Rep. 2023; 42(1): 112017.
Qi X， Cui K， Zhang Y， Wang L， Tong J， Sun W， Shao S伦理高清百度影音， Wang J， Wang C， Sun X， Xiao L， Xi K， Cui S， Liu F， Ma L， Zheng J， Yi M， Wan Y. A nociceptive neuronal ensemble in dorsomedial prefrontal cortex underlies pain chronicity. Cell Rep. 2022; 41(11):111833.
Sun H， Fu S， Yin X， Sun X， Qi X， Cui K， Wang J， Ma L， Liu FY， Cui S， Liao FF， Wang XH， Yi M， Wan Y. Development of CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain. Sci Adv. 2020; 6: eaay6687.
Ma L， Yue L， Zhang Y， Wang Y， Han B， Cui S， Liu FY， Wan Y， Yi M. Spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex connectivity and modulates pain progression in rats with peripheral inflammation. Cell Rep. 2019;29:1579–1593.
Jiang Y， Shao S， Zhang Y， Zheng J， Chen X， Cui S， Liu FY， Wan Y， Yi M. Neural pathways in medial septal cholinergic modulation of chronic pain: distinct contribution of anterior cingulate cortex and ventral hippocampus. Pain. 2018. 159(8):1550-1561.
Zheng J， Jiang YY， Xu LC， Ma LY， Liu FY， Cui S， Cai J， Liao FF， Wan Y， Yi M. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice. J Neurosci. 2017; 37(15):4145-4157.
Funding
2023 National Natural Science Foundation (32271053) 2023 Beijing Natural Science Foundation (L222016) 2019 National Natural Science Foundation (31872774) 2018 Beijing Natural Science Foundation (5182013) 2015 National Basic Research Program of MOST(2015CB554503) 2014National Basic Research Program of MOST(2014CB548200) 2012 National Natural Science Foundation (31200835)
伊鸣 博士
磋商口头：
地址：北京市海淀区学院路38号北京大学神经科学商讨所
邮编：100191
电话：(010)82805083
E-mail: mingyi@hsc.pku.edu.cn
学术履历：
于北京大学医学部临床医学专科获医学学士学位，英国伦敦大学学院（University College London， UCL）剖解与发育生物学系神经科学专科获形而上学博士学位（导师John O’Keefe西席，英国皇家科学院、皇家医学院、好意思国科学院院士，2014年诺贝尔生理学或医学奖取得者）。现任北京大学神经科学商讨所贯通神经科学施行室商讨员。
商讨见解：操心解码、操控与功能重建
学习与操心是进攻的贯通功能，而病感性操心是创伤后应激壅塞、慢性痛等多种神经精神系统疾病的共有特征。咱们辘集运用在体与离体电生理记载、双光子钙成像、光/化学遗传学、分子生物学等多项先进时刻，开展脑功能尤其是操心功能的解码、操控与功能重建商讨，并针对多种神经精神疾病设置新式临床调养时刻。
（1）操心的精确操控与功能重建
操心陈迹由世俗永诀在海马、新皮层等脑区的印迹细胞群编码并储存。咱们运用通过通路特异性及功能特异性神经元亚群的基因剪辑时刻，竣事了特定懦弱操心的精确删除（Sci Adv. 2020）。咱们进一步说明编码懦弱操心的印迹细胞群止境举止所以懦弱泛化为特征的神经精神类疾病中贯通与心思变化的关键神经元基础（PLoS Biol. 2024）。基于以上发现，咱们正在沟通多个小分子物资及神经调控时刻在创伤后应激壅塞、围手术期神经贯通壅塞等疾病中重建操心功能的后劲。
（2）痛操心的细胞与神经回路基础
疾苦是包含嗅觉、心思、贯通和社会身分的多维度表象。慢性痛被以为是伤害性嗅觉与心思的病感性操心。由于不存在特定脑区特意编码疾苦信号，瓦解疾苦信息的编码机制是高挑战性责任。咱们先后报说念了啮齿类慢性痛动物模子中前额叶皮层编码诱发痛（Cell Rep. 2022）、自觉痛（Cell Rep. 2019）和慢性痛共病狂躁（Autophagy. 2024）的神经元亚群及回路，并揭示脑边际系统参与疾苦编码与调控的神经回路机制（J Neurosci. 2017; Pain. 2018; Cell Rep. 2023）。
三级片（3）幼儿脑功能评估与康复
更生儿脑毁伤、发育及功能的精确评估是要紧临床需求，胜仗关系到赤子脑瘫、发育渐渐、孤立孤身一人症等多类幼儿脑疾病的风险预警、临床会诊、疗效评估和长期预后。咱们设置了基于视频自动识别跟踪与东说念主工智能时刻的幼儿全身指引自动评估系统，以竣事轨范化、辛劳化、客不雅化的更生儿脑功能评估（Med Image Anal. 2024; Displays. 2024）。现在，咱们正在设置一系列运用于不同庚级段幼儿的脑功能评估与康复时刻。
代表性论文
Cui K， Qi X， Liu L， Jiao P， Tong J， Sun X， Sun H， Fu S， Wang J， Zheng Y， Liu T， Cui S， Liu F， Zheng J， Wan Y， Yi M. Dominant activities of fear engram cells in the dorsal dentate gyrus underlies fear generalization. PLoS Biol. 2024. In press
Yin W， Chen L， Huang X， Huang C， Wang Z， Bian Y， Wan Y， Zhou Y， Hang T， Yi M. A self-supervised spatio-temporal attention network for video-based 3D infant pose estimation. Med Image Anal. 2024. 96:103208
Huang X， Huang C， Yin W， Huang H， Xie Z， Huang Y， Chen M， Fan X， Shang X， Peng Z， Wan Y， Han T， Yi M. Automatic quantitative intelligent assessment of neonatal general movements with video tracking. Displays. 2024. 82:102658
Fu S， Sun H， Wang J， Gao S， Zhu L， Cui K， Liu S， Qi X， Guan R， Fan X， Liu Q， Chen W， Su L， Cui S， Liao F， Liu F， Wong CL， Yi M， Wan Y. Impaired neuronal macroautophagy in the prelimbic cortex contributes to comorbid anxiety-like behaviors in rats with chronic neuropathic pain. Autophagy. 2024. Mar 24:1-18
Shao S， Zheng Y， Fu Z， Wang J， Zhang Y， Wang C， Qi X， Gong T， Ma L， Lin X， Yu H， Wan Y， Zhang H， Yi M. Ventral hippocampal CA1 modulates pain behaviors in mice with peripheral inflammation. Cell Rep. 2023; 42(1): 112017.
Qi X， Cui K， Zhang Y， Wang L， Tong J， Sun W， Shao S， Wang J， Wang C， Sun X， Xiao L， Xi K， Cui S， Liu F， Ma L， Zheng J， Yi M， Wan Y. A nociceptive neuronal ensemble in dorsomedial prefrontal cortex underlies pain chronicity. Cell Rep. 2022; 41(11):111833.
Sun H， Fu S， Yin X， Sun X， Qi X， Cui K， Wang J， Ma L， Liu FY， Cui S， Liao FF， Wang XH， Yi M， Wan Y. Development of CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain. Sci Adv. 2020; 6: eaay6687.
Ma L， Yue L， Zhang Y， Wang Y， Han B， Cui S， Liu FY， Wan Y， Yi M. Spontaneous pain disrupts ventral hippocampal CA1-infralimbic cortex connectivity and modulates pain progression in rats with peripheral inflammation. Cell Rep. 2019;29:1579–1593.
Jiang Y， Shao S， Zhang Y， Zheng J， Chen X， Cui S， Liu FY， Wan Y， Yi M. Neural pathways in medial septal cholinergic modulation of chronic pain: distinct contribution of anterior cingulate cortex and ventral hippocampus. Pain. 2018. 159(8):1550-1561.
Zheng J， Jiang YY， Xu LC， Ma LY， Liu FY， Cui S， Cai J， Liao FF， Wan Y， Yi M. Adult hippocampal neurogenesis along the dorsoventral axis contributes differentially to environmental enrichment combined with voluntary exercise in alleviating chronic inflammatory pain in mice. J Neurosci. 2017; 37(15):4145-4157.
科研资助与奖励
2023年国度当然科学基金（32271053）
2023北京市当然科学基金-海淀原始立异辘集基金（L222016）
2019年国度当然科学基金（31872774）
2019年北京市后生东说念主才托举料到
2018年北京当然科学基金（5182013）
2015年国度重心基础商讨发展料到（973料到）（2015CB554503）
2014年973料到后生科学家专题（2014CB548200）
2012年国度当然科学基金（31200835）
2015年国度科学时刻跨越奖二等奖（5/10）
教授
本科生课程《科研想维历练》：神经生物学
本科生课程《医理工信前沿拓展》：神经元操控
商讨生课程《高等神经生物学》：脑的高等贯通功能
商讨生课程《神经科学施展》：海马脑区生理与功能商讨施展
商讨生课程《神经生物学施行》：流露动物在体电生理记载与光遗传学时刻
商讨生课程《激情危坎坷难》：操心与情谊的神经生物学基础
2014年于今北京大学医学部教师教授发展中心培教授师
2017年北京大学医学部教授优秀奖
2014年中华医学会医学栽种分会第四届医学（医药）院校后生教师教授基本功比赛稀薄奖，最受学生接待奖，最好教案奖
2013年北京高校第八届后生教师教授基本功比赛一等奖，最受学生接待奖，最好演示奖
2013年北京大学医学部教授优秀奖
2012年北京大学第十二届后生教师教授演示竞赛（医科类）一等奖
2012年北京大学基础医学院第十二届后生教师教授演示竞赛一等奖